What is Lisinopril? – used to treat high blood pressure, heart failure, and after heart attacks.

What is Lisinopril? – used to treat high blood pressure, heart failure, and after heart attacks.

Lisinopril is a medicine, form of the angiotensin-converting enzyme (ACE) inhibitor class which applied for the treatment of hypertension and congestive heart failure. In 1978 Lisinopril patented and authorised for the medical use in the United States in 1987. This is a synthetic peptide derivative of Captopril. The medicine, Lisinopril was invented by scientists at Merck to overcome the rash and lousy taste caused by Captopril. Moreover, Merck spread the drug through clinical trials and after that
This approved for hypertension in 1987 and congestive heart in 1933. It is considering as generic medication, and This was the 2nd most prescribed medicine in the United States.

What does Lisinopril Look?

This medicine is marketed in different brand names by various medicine manufacturers. Lisinopril is available in both dosage forms of round and elliptical/oval shape in Tablets and solution. White, Blue, Yellow, and Pink coloured tablets manufactured by different pharmaceutical companies.


Brand Names  : Zestril, Prinivil, Qbrelis

Generic Names: Lisinopril

Chemical formula: C21H31N3O5

DrugBank ID    : DB00722


Lisinopril is inhibiting angiotensin-converting enzyme (ACE) in the renin-angiotensin-aldosterone system (RAAS), reserving angiotensin I form is converted to angiotensin II. Lisinopril avoids the release of aldosterone from the adrenal cortex, which gives the kidney to excrete sodium along with water into the urine, and retention of potassium ions. Specifically, this process in the particular capillaries of the organs in response to a change in starling forces. The inhibition of the RAAS system causes an overall decrease in blood pressure.


Lisinopril is typically approved for the treatment of high blood pressure, congestive heart failure, diabetic nephropathy and acute myocardial infarction (heart attack). According to scientists, Lisinopril was an effective medication for proteinuric kidney disease, including diabetic proteinuria. It could take once daily by mouth with or without food as per the instructions of the doctor.

Food Effects: Herbs that may weaken the antihypertensive effect of Lisinopril consist: Bayberry, Blue cohosh, Cayenne, Ephedra, Ginger, Ginseng, Kola and Licorice.

Important Information:

  • Keep this medicine away and out of reach from children.
  • Do not keep outdated medicine or medicine no longer needed.
  • Ask your health care professional how you should dispose of any medicine you do not use.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
  • Store the mixed oral liquid at or below room temperature for up to 4 weeks
  • Use Lisinopril with the instruction of Doctor never share your medicines with others.
  • Alcohol may further reduce your blood pressure and increase some adverse effects of Lisinopril.
  • Avoid becoming overheated and dehydrated during exercise at high temperature or not drinking enough fluids. Drink more water while you are taking this medication.
  • Lisinopril never recommends to the pregnant mother since it can be harmful to the unborn baby.

Adverse effects:

The way of adverse effects depend and change according to the disease. Mainly there are common side effects Blurred vision, cloudy urine, confusion, a decrease in urine output or decrease in urine-concentrating ability, sweating, unusual tiredness or weakness, etc. Hence some effects categorised with the diseases as below.

blood pressure, heart failure, and after heart attacks.
Table 1: Adverse effects of using Lisinopril to the diseases of Hypertension, Myocardial Infarction and Heart failure.


The doctor should prescribe lisinopril medicine, and typical dosages can be tabulated as follows:

Table 1 : Lisinopril dosage for Hypertension
Table 2: Lisinopril dosage for Congestive heart failure, Diabetic nephropathy and Myocardial infarction

Other Interactions

A drug interaction may directly or indirectly affect the medication work or tends to the severe side effects. Maintain a list of medicine you use and don’t start, change or stop dosage of a drug without a doctor’s prescription.

  • Some products may interact with Lisinopril: Aliskiren, Lithium
  • Some drugs weaken the immune system: Everolimus, Sirolimus
  • Some drugs caused to increase the level of potassium in the blood: ARBs including Losartan/Valsartan, birth control pills.
  • Especially some products (Cough and cold products, diet aids) included ingredients that may increase blood pressure etc.

A broad spectrum antibiotic “Clavamox” from a pet pharmacy



Zoe Mart Official Witter

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